Anti counterfeiting technology of the hottest phar

The World Health Organization spokesperson announced in Geneva that 10% of the drugs sold worldwide are fake drugs, and the annual sales of fake drugs reach US $32billion. Similarly, due to the further opening of the drug market and the fashion of purchasing drugs, the problem of fake drugs has also seriously troubled the European pharmaceutical market. The prevention and treatment of counterfeit goods has become the top priority to protect the health and safety of consumers. Drug packaging anti-counterfeiting has become an important and indispensable part of drugs. The anti-counterfeiting of pharmaceutical packaging, like the development of medicine, is also impacted by counterfeiting

first, foreign countries attach great importance to pharmaceutical anti-counterfeiting

European pharmaceutical packaging manufacturers design and produce a large number of new generation anti-counterfeiting packaging. There are nearly 10 kinds of anti-counterfeiting marks on a kind of medicine box less than palm size produced by German Tess company. It uses miniature characters, glazing and plate making. At the same time, it uses anti-counterfeiting marks that can be recognized by the naked eye, such as banknote gravure printing technology, and anti-counterfeiting marks for the determination of fracture toughness of fine ceramic materials that can be seen only with special lenses. Not only that, the company also printed anti-counterfeiting logos that only a few people know, and constantly developed and updated anti-counterfeiting logos. In addition, the company often sends special personnel to pretend to be customers to conduct spot checks on the market

European pharmaceutical packaging suppliers have adopted a strict audit qualification system and implemented corresponding standards. Pharmaceutical packaging suppliers must first pass the ISO9001 certification and be audited by pharmaceutical companies. Drug box manufacturers and packaging suppliers must plan production processes according to the strict requirements of government departments, so a standard applicable to all industries came into being. In addition, there is a special inspection catalogue for medicine boxes, labels, rubber and other packages. In order to facilitate management, the German pharmaceutical industry has also established a "pharmaceutical packaging quality association". The association reviews the packaging suppliers every two years, mainly to check whether they have ISO9001 qualification certificate, and then strictly review them one by one according to the inspection catalogue of the association. After reviewing the pharmaceutical factory, the special commissioner of the head of the German government fully agreed that the pharmaceutical factory took the quality standard designated by the quality association as the warehousing inspection standard of the pharmaceutical packaging materials. In this way, in actual production, only products that have been spot checked by the pharmaceutical packaging quality association can be directly used in production

in Europe, once fake drugs appear in prescriptions, pharmaceutical manufacturers and drug packaging suppliers will bear corresponding and obligations respectively. If the patient is injured due to taking fake drugs, the pharmaceutical factory must show its anti-counterfeiting Certificate in court. If the pharmaceutical factory has not done or done little in this regard, it can be defined as "weak organization", and it must undertake its due obligations. If the pharmaceutical factory has done all its strength in technology, it can be exempted from punishment. The packaging supplier proved the authenticity of the kit when a lawsuit occurred. For this reason, suppliers have introduced very special identification technology in the production process, and only a few people know these identifications, and some even pharmaceutical companies do not know them. Only in this way can we guarantee to prove the authenticity of the medicine box in court, maintain the reputation of the enterprise and protect the health and safety of consumers

Second, the important technology of anti-counterfeiting of pharmaceutical packaging

anti counterfeiting technology is an interdisciplinary subject, involving optics, chemistry, physics, electromagnetism, computer technology, spectrum technology, printing technology, packaging technology and many other fields. In the process of fighting wits and courage with counterfeiters, the anti-counterfeiting technology of pharmaceutical flexible packaging is also constantly improving. For example, from the perspective of anti-counterfeiting materials, it can be divided into: laser anti-counterfeiting technology (laser coating, positioning laser hot stamping, non positioning laser hot stamping, true color laser photopolymer), anti-counterfeiting ink (thermal color changing ink, light changing ink, etc.), watermark anti-counterfeiting paper, fiber composite anti-counterfeiting paper, nuclear track anti-counterfeiting, network anti-counterfeiting (code anti-counterfeiting, code spray anti-counterfeiting), etc. In terms of anti-counterfeiting processing methods, it can be divided into: printing anti-counterfeiting, plate making (plate pattern) anti-counterfeiting, labeling anti-counterfeiting, film coating anti-counterfeiting, ultimately producing 210000 tons/year low-density polyethylene, 100000 tons/year EVA, 35000 tons/year ultra-high molecular weight polyethylene, 430000 tons/year pp-icp/rcp The annual coal consumption of the project is about 4.7 million tons, such as hot stamping and anti-counterfeiting

1. RFID tag

phase jitter adjustment (PJM) was invented by Magellan technology company, which studies high-frequency RFID technology in Australia. It is trying to get support from the pharmaceutical industry. UPM Raflatac is establishing a new high-frequency label production line, which will produce RFID chips based on phase jitter adjustment technology

magellan technology believes that labels with PJM technology have a relatively high reading rate, even in an environment with a considerable number of labels within the readable range. Therefore, both Raflatac and Magellan believe that this newly developed high-frequency label is more suitable for single product labels in the pharmaceutical industry. If pharmaceutical enterprises choose PJM technology and Magellan label, their supply chain partners also need to invest in the same technology. Although this is a little unreasonable, Magellan firmly believes that the benefits from HF and Magellan's technology are enough to win the trust of customers in the pharmaceutical industry

in the pharmaceutical industry, UHF (ultra high frequency) and HF (high frequency) labels are used in the supply chain. The debate about which is more suitable for single product label tracking continues. For example, do products in the pharmaceutical industry need to be read at the same time of labeling? Nevertheless, Magellan believes that high-frequency system has more advantages than UHF, because high-frequency technology is more mature and the range of reading is smaller. The pharmaceutical industry is characterized by high density and large quantity in production and transportation. In this case, the reading range with low frequency seems to be more suitable. An HF card reader can focus on a small area, so that the label can only be read within a few inches, and will not be disturbed by adjacent labels

2. Bar code

every year, there are not a few patients who die due to medical accidents in hospitals, mainly because patients get the wrong drugs or doses. Many drugs have similar names, which are difficult to distinguish, and the diseases they target may be completely different. Barcode is the best way to avoid making mistakes about drugs. Relevant drug administration agencies suggest that it is best to use bar codes for drugs used in hospitals. Including the national drug number, service life and batch number. In addition, the barcode must be printed on the package of the smallest unit of use. The adoption of bar codes will reduce the new costs faced by pharmaceutical manufacturers in the future, and bring greater positive effects to consumers and health insurance

it is urgent to adopt bar code management for drugs. In foreign countries, bar code has been widely used in drug sales, but this work has not been widely carried out in China. Bar code is the "ID card" of drugs. Under the current situation of fake drugs, bar code plays an important role in blocking fake drugs from entering the market, and plays an important role in anti-counterfeiting, reducing circulation links, and promoting modern logistics

according to the China Article Numbering Center, 75 of the 300 pharmaceutical enterprises in Shanghai have applied to register as members of the commodity barcode system. However, the use of bar code is not satisfactory. Most manufacturers register bar codes only to meet the requirements of the international market for bar codes, which are only used on export products. At present, most drug producers are waiting for the formation of the "general climate" of the market, while drug sellers are hoping that producers can use bar codes immediately. Because the current benefits can not be immediately reflected, drug manufacturers and distributors have fallen into a stalemate with each other. At present, it is difficult to achieve self-regulation by relying solely on the market under the condition that it is impossible to comply with mandatory restrictions. The time has come for drugs to be equipped with "ID cards"

with the emergence of heat transfer printing and laser machines, the traditional inkjet technology is facing challenges. The latest challenge of drug packaging is to carry out high-quality printing on high-speed packaging production lines and online verification of bar codes. For more advanced equipment, its tasks also include printing product batch numbers and effective dates with two-dimensional symbols, and combining barcode printing with electronic inkjet technology (such as RFID technology for wireless frequency identification). The bar code on drugs has been printed by flexographic printing for a long time, and drug companies will still use this technology when printing fixed content. Inkjet printing, heat transfer printing and laser printing are rapidly becoming competitors of flexographic printing, because they can reprogram in cooperation with some material companies and small equipment factories without changing tools. In the past few years, HP has been cooperating with several printing machine suppliers to provide thermal inkjet printheads, so that high-resolution (600dpi) characters can be printed on paper or t yvek materials

in the past few years, RFID tag system with barcode and electronic product coding technology (EPC) has gradually been adopted. Markem can provide corresponding systems for RFID tags used on cartons and carton packaging. The system is suitable for high-speed production lines. With the help of computer software, it ensures that the EPC code is correctly and uniquely programmed into the tag. Njm/cli's auto coltiii pressure sensitive labeling machine can be used to inspect RFID tags. Sato America also launched a thermal barcode printer for the second generation RFID technology

3. ink anti-counterfeiting technology

ink anti-counterfeiting technology is a widely used anti-counterfeiting technology in the pharmaceutical packaging industry at present. This kind of anti-counterfeiting technology mainly uses the technology of adding special substances into the common ink connecting material and becoming special printing ink after special processing. This kind of anti-counterfeiting technology is characterized by simple implementation, low cost, good concealment, bright colors and convenient inspection. At present, anti-counterfeiting inks mainly include UV excited fluorescent anti-counterfeiting inks, magnetic anti-counterfeiting inks, thermal color changing anti-counterfeiting inks, sunlight excited color changing anti-counterfeiting inks, optical variable anti-counterfeiting inks, pressure-sensitive anti-counterfeiting inks, infrared anti-counterfeiting inks, anti alteration anti-counterfeiting inks, anti counterfeiting inks, etc

ink printing anti-counterfeiting is an important part of the anti-counterfeiting technology of pharmaceutical packaging. Experiments show that the fluorescent anti-counterfeiting ink with fluorescent pigments has good water resistance, acid resistance and alcohol resistance. At present, it is widely used in pharmaceutical packaging, especially blister packaging. It is also often used in other drug packaging, such as drug flexible packaging and drug labels. It can be said that fluorescent anti-counterfeiting ink is the most widely used anti-counterfeiting ink in the anti-counterfeiting of pharmaceutical packaging ink at present

fluorescent ink is made by adding corresponding visible fluorescent compounds to the ink. Its anti-counterfeiting feature is that printed matter can emit glittering fluorescence under the action of visible light and ultraviolet light. Different formulas can get different fluorescent inks. For example, UV fluorescent ink can be obtained by adding UV excited visible fluorescent compounds (such as stilbene derivatives, stilbene derivatives, tetrastyrene derivatives, etc.) to the ink, which can emit red, yellow, green, blue and other visible light under UV irradiation. Infrared fluorescent ink can be obtained by adding visible fluorescent compounds with infrared excitation to the ink. Secretary General Zheng Long said, "take the automobile industry as an example, it can emit green visible light.

4. Laser holographic image technology

laser hologram